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Sequencing Systems
Sequencing Without Limits
From everyday research to tomorrow’s innovations, it all starts with Illumina.
Whether you're running targeted assays or decoding thousands of genomes, the right sequencing platform makes all the difference. Illumina, the global leader in next-generation sequencing, delivers trusted performance, flexible scalability, and unmatched data quality across every application area.
With over two decades of innovation, 420,000+ scientific publications, and systems powering labs around the world, Illumina technology has become the foundation of modern genomics.
Find your fit.
Explore our sequencing portfolio, powered by cutting-edge XLEAP-SBS™ chemistry and integrated DRAGEN™ analysis:
From benchtop simplicity to production-scale capacity,
your next discovery starts here.
your next discovery starts here.
MiSeq™ i100 Series
The new standard in fast and simple benchtop sequencing
Same-day results. Simplified workflow.
- Run time as fast as 4 hours
- Setup in less than 20 minutes
- Onboard DRAGEN™ secondary analysis — no need for bioinformatics expertise
Powered by XLEAP-SBS™ chemistry
- Exceptional accuracy: >90% of bases above Q30
- Room-temperature reagent storage — no thawing needed
- Sustainable design with ~85% packaging reduction
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Feature
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MiSeq i100
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MiSeq i100 Plus
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|---|---|---|
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Data Output
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1.5–15 Gb
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1.5–30 Gb
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Flow Cell Types
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5M, 25M
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5M, 25M, 50M, 100M
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Max Reads
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25M
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100M
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Small whole-genome sequencing (WGS)
Microbial and infectious disease genomics
RNA-Seq & gene expression
Targeted gene sequencing
NextSeq™ 1000& 2000
Scalable benchtop power for mid-throughput sequencing
Flexible. Fast. Built for modern NGS labs.
- Push-button simplicity with load-and-go cartridges
- Integrated DRAGEN™ secondary analysis onboard
- Reduced hands-on time, no post-run wash required
- Intuitive UI and simplified setup in ~30 minutes
Powered by XLEAP-SBS™ chemistry
- Exceptional accuracy and speed
- Room-temperature reagent storage
- Reduced waste with recyclable components
P4 Flow Cell: Benchtop meets powerhouse
- Delivers up to 1.6 billion reads, rivaling NovaSeq™ X Plus 1.5B flow cell
- Ideal for large RNA-Seq projects, whole transcriptome, and high-depth panels
- Scale without moving to a core facility
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Feature
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NextSeq 1000
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NextSeq 2000
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|---|---|---|
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Data Output
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Up to 120 Gb
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Up to 540 Gb
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Flow Cell Types
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P1, P2
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P1, P2, P3, P4
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Max Reads
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400M
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1.8B
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Whole-exome sequencing (WES)
Comprehensive cancer panels (CGP)
Gene expression and single-cell RNA-Seq
Microbial profiling and metagenomics
NovaSeq™ X Series
Next‑level, ultra‑high‑throughput sequencing for production‑scale genomics
Designed for performance & sustainability
- Room-temperature shipped lyophilized reagents
- Up to 90% reduction in packaging waste
Flow Cell Options – Scalable Power
- 1.5B → ~500 Gb | ~1.6B reads
- 10B → ~3 Tb | ~10B reads
- 25B → ~8 Tb | ~26B reads
Up to 16 Tb
52 billion reads per dual run
DRAGEN™ for secondary analysis
